Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder

Xiaoyuan Niu; Ying Xu; Qiaoling Yang; Xiaowen Tang; Li Yang; Zhengtao Wang

doi:doi:10.11648/j.ajac.20140206.11

| Peer-Reviewed

Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder

Xiaoyuan Niu, Ying Xu, Qiaoling Yang, Xiaowen Tang, Li Yang, Zhengtao Wang

Published in American Journal of Applied Chemistry (Volume 2, Issue 6)

Received: 12 November 2013 Accepted: 28 November 2014 Published: 27 November 2014

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Abstract

Bile acids as characteristic compounds of human and animal bile are major endogenous products of cholesterol and play very important roles in cholesterol homeostasis, lipid absorption and production of bile flow. At present, bile acids are useful biomarkers and signaling molecules for the diagnosis or treatment of many diseases in clinic. Various analytical methods, from overall to individual, qualitative to quantitative, have been developed for the determination of bile acids in biomedical samples and even bile-based medicinal materials. The most precious and commonly-used bile-based traditional animal medicines are cow-bezoar (CB) and bear bile powder (BBP), which regard bile acids as the main bioactive constituents and have extensive use for treating many diseases since thousands of years ago. However, extensive consumption of CB and BBP make their natural resource scarcity and price valuableness. Currently, artificial, in-vitro cultured substitutes and even worse adulterants or counterfeits mix in the medicine market and they have seriously compromised the therapeutic effects of these two traditional medicines. To guarantee the long-term development of ethnodrugs, many analytical approaches have been utilized in quality control of CB and BBP. In this paper, various analytical methods of bile acids are summarized and compared with each other.

Published in	American Journal of Applied Chemistry (Volume 2, Issue 6)
DOI	10.11648/j.ajac.20140206.11
Page(s)	96-104
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Bile Acids, Analytical Methods, Cow-Bezoar, Bear Bile Powder, Quality Control

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Xiaoyuan Niu, Ying Xu, Qiaoling Yang, Xiaowen Tang, Li Yang, et al. (2014). Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder. American Journal of Applied Chemistry, 2(6), 96-104. https://doi.org/10.11648/j.ajac.20140206.11

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Xiaoyuan Niu; Ying Xu; Qiaoling Yang; Xiaowen Tang; Li Yang, et al. Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder. Am. J. Appl. Chem. 2014, 2(6), 96-104. doi: 10.11648/j.ajac.20140206.11

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Xiaoyuan Niu, Ying Xu, Qiaoling Yang, Xiaowen Tang, Li Yang, et al. Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder. Am J Appl Chem. 2014;2(6):96-104. doi: 10.11648/j.ajac.20140206.11

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@article{10.11648/j.ajac.20140206.11,
  author = {Xiaoyuan Niu and Ying Xu and Qiaoling Yang and Xiaowen Tang and Li Yang and Zhengtao Wang},
  title = {Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder},
  journal = {American Journal of Applied Chemistry},
  volume = {2},
  number = {6},
  pages = {96-104},
  doi = {10.11648/j.ajac.20140206.11},
  url = {https://doi.org/10.11648/j.ajac.20140206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20140206.11},
  abstract = {Bile acids as characteristic compounds of human and animal bile are major endogenous products of cholesterol and play very important roles in cholesterol homeostasis, lipid absorption and production of bile flow. At present, bile acids are useful biomarkers and signaling molecules for the diagnosis or treatment of many diseases in clinic. Various analytical methods, from overall to individual, qualitative to quantitative, have been developed for the determination of bile acids in biomedical samples and even bile-based medicinal materials. The most precious and commonly-used bile-based traditional animal medicines are cow-bezoar (CB) and bear bile powder (BBP), which regard bile acids as the main bioactive constituents and have extensive use for treating many diseases since thousands of years ago. However, extensive consumption of CB and BBP make their natural resource scarcity and price valuableness. Currently, artificial, in-vitro cultured substitutes and even worse adulterants or counterfeits mix in the medicine market and they have seriously compromised the therapeutic effects of these two traditional medicines. To guarantee the long-term development of ethnodrugs, many analytical approaches have been utilized in quality control of CB and BBP. In this paper, various analytical methods of bile acids are summarized and compared with each other.},
 year = {2014}
}

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TY  - JOUR
T1  - Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder
AU  - Xiaoyuan Niu
AU  - Ying Xu
AU  - Qiaoling Yang
AU  - Xiaowen Tang
AU  - Li Yang
AU  - Zhengtao Wang
Y1  - 2014/11/27
PY  - 2014
N1  - https://doi.org/10.11648/j.ajac.20140206.11
DO  - 10.11648/j.ajac.20140206.11
T2  - American Journal of Applied Chemistry
JF  - American Journal of Applied Chemistry
JO  - American Journal of Applied Chemistry
SP  - 96
EP  - 104
PB  - Science Publishing Group
SN  - 2330-8745
UR  - https://doi.org/10.11648/j.ajac.20140206.11
AB  - Bile acids as characteristic compounds of human and animal bile are major endogenous products of cholesterol and play very important roles in cholesterol homeostasis, lipid absorption and production of bile flow. At present, bile acids are useful biomarkers and signaling molecules for the diagnosis or treatment of many diseases in clinic. Various analytical methods, from overall to individual, qualitative to quantitative, have been developed for the determination of bile acids in biomedical samples and even bile-based medicinal materials. The most precious and commonly-used bile-based traditional animal medicines are cow-bezoar (CB) and bear bile powder (BBP), which regard bile acids as the main bioactive constituents and have extensive use for treating many diseases since thousands of years ago. However, extensive consumption of CB and BBP make their natural resource scarcity and price valuableness. Currently, artificial, in-vitro cultured substitutes and even worse adulterants or counterfeits mix in the medicine market and they have seriously compromised the therapeutic effects of these two traditional medicines. To guarantee the long-term development of ethnodrugs, many analytical approaches have been utilized in quality control of CB and BBP. In this paper, various analytical methods of bile acids are summarized and compared with each other.
VL  - 2
IS  - 6
ER  -

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Author Information

Xiaoyuan Niu

The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Ying Xu

The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Qiaoling Yang

The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Xiaowen Tang

The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Li Yang

The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
Zhengtao Wang

The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China

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APA Style

Xiaoyuan Niu, Ying Xu, Qiaoling Yang, Xiaowen Tang, Li Yang, et al. (2014). Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder. American Journal of Applied Chemistry, 2(6), 96-104. https://doi.org/10.11648/j.ajac.20140206.11

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ACS Style

Xiaoyuan Niu; Ying Xu; Qiaoling Yang; Xiaowen Tang; Li Yang, et al. Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder. Am. J. Appl. Chem. 2014, 2(6), 96-104. doi: 10.11648/j.ajac.20140206.11

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AMA Style

Xiaoyuan Niu, Ying Xu, Qiaoling Yang, Xiaowen Tang, Li Yang, et al. Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder. Am J Appl Chem. 2014;2(6):96-104. doi: 10.11648/j.ajac.20140206.11

Copy | Download

@article{10.11648/j.ajac.20140206.11,
  author = {Xiaoyuan Niu and Ying Xu and Qiaoling Yang and Xiaowen Tang and Li Yang and Zhengtao Wang},
  title = {Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder},
  journal = {American Journal of Applied Chemistry},
  volume = {2},
  number = {6},
  pages = {96-104},
  doi = {10.11648/j.ajac.20140206.11},
  url = {https://doi.org/10.11648/j.ajac.20140206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20140206.11},
  abstract = {Bile acids as characteristic compounds of human and animal bile are major endogenous products of cholesterol and play very important roles in cholesterol homeostasis, lipid absorption and production of bile flow. At present, bile acids are useful biomarkers and signaling molecules for the diagnosis or treatment of many diseases in clinic. Various analytical methods, from overall to individual, qualitative to quantitative, have been developed for the determination of bile acids in biomedical samples and even bile-based medicinal materials. The most precious and commonly-used bile-based traditional animal medicines are cow-bezoar (CB) and bear bile powder (BBP), which regard bile acids as the main bioactive constituents and have extensive use for treating many diseases since thousands of years ago. However, extensive consumption of CB and BBP make their natural resource scarcity and price valuableness. Currently, artificial, in-vitro cultured substitutes and even worse adulterants or counterfeits mix in the medicine market and they have seriously compromised the therapeutic effects of these two traditional medicines. To guarantee the long-term development of ethnodrugs, many analytical approaches have been utilized in quality control of CB and BBP. In this paper, various analytical methods of bile acids are summarized and compared with each other.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Analytical Methods for Characterization of Bile Acids and Its Application in Quality Control of Cow-Bezoar and Bear Bile Powder
AU  - Xiaoyuan Niu
AU  - Ying Xu
AU  - Qiaoling Yang
AU  - Xiaowen Tang
AU  - Li Yang
AU  - Zhengtao Wang
Y1  - 2014/11/27
PY  - 2014
N1  - https://doi.org/10.11648/j.ajac.20140206.11
DO  - 10.11648/j.ajac.20140206.11
T2  - American Journal of Applied Chemistry
JF  - American Journal of Applied Chemistry
JO  - American Journal of Applied Chemistry
SP  - 96
EP  - 104
PB  - Science Publishing Group
SN  - 2330-8745
UR  - https://doi.org/10.11648/j.ajac.20140206.11
AB  - Bile acids as characteristic compounds of human and animal bile are major endogenous products of cholesterol and play very important roles in cholesterol homeostasis, lipid absorption and production of bile flow. At present, bile acids are useful biomarkers and signaling molecules for the diagnosis or treatment of many diseases in clinic. Various analytical methods, from overall to individual, qualitative to quantitative, have been developed for the determination of bile acids in biomedical samples and even bile-based medicinal materials. The most precious and commonly-used bile-based traditional animal medicines are cow-bezoar (CB) and bear bile powder (BBP), which regard bile acids as the main bioactive constituents and have extensive use for treating many diseases since thousands of years ago. However, extensive consumption of CB and BBP make their natural resource scarcity and price valuableness. Currently, artificial, in-vitro cultured substitutes and even worse adulterants or counterfeits mix in the medicine market and they have seriously compromised the therapeutic effects of these two traditional medicines. To guarantee the long-term development of ethnodrugs, many analytical approaches have been utilized in quality control of CB and BBP. In this paper, various analytical methods of bile acids are summarized and compared with each other.
VL  - 2
IS  - 6
ER  -

Copy | Download