Background: Inflamed large facial patch, being compromising the appearance and beauty of a patient, is a source of embarrassment and distress, and affects anti-leprosy drive adversely in many ways in the field situation. Its management with oral prednisolone alone, the mainstay of treatment for reversal reaction, proved disappointing. Objective: To see whether topical tacrolimus will be helpful in managing those patients. Methodology: We treated five adult patients with recurring reversal reaction in large facial patch with tacrolimus 0.1% ointment, twice daily and lower dose oral prednisolone for twelve months during March, 2012-February, 2013. Result: Complete remission was achieved in all cases. No side effects of whatsoever was seen in any patient. No recurrence of reaction is seen in any patient till to date. Conclusion: Tacrolimus ointment and lower dose prednisolone was found helpful in managing patients with recurring reversal reaction in large facial patch.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 2, Issue 4) |
| DOI | 10.11648/j.ajcem.20140204.16 |
| Page(s) | 86-89 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Leprosy, Reversal Reaction, Reacting Facial Patch, Management, Tacrolimus and Prednisolone
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APA Style
Delwar Hossain. (2014). Tacrolimus in the Management of Large Facial Patch with Recurring Reversal Reaction: Outcome of a Pilot Clinical Trial Study on 5 Patients. American Journal of Clinical and Experimental Medicine, 2(4), 86-89. https://doi.org/10.11648/j.ajcem.20140204.16
ACS Style
Delwar Hossain. Tacrolimus in the Management of Large Facial Patch with Recurring Reversal Reaction: Outcome of a Pilot Clinical Trial Study on 5 Patients. Am. J. Clin. Exp. Med. 2014, 2(4), 86-89. doi: 10.11648/j.ajcem.20140204.16
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Download@article{10.11648/j.ajcem.20140204.16,
author = {Delwar Hossain},
title = {Tacrolimus in the Management of Large Facial Patch with Recurring Reversal Reaction: Outcome of a Pilot Clinical Trial Study on 5 Patients},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {2},
number = {4},
pages = {86-89},
doi = {10.11648/j.ajcem.20140204.16},
url = {https://doi.org/10.11648/j.ajcem.20140204.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20140204.16},
abstract = {Background: Inflamed large facial patch, being compromising the appearance and beauty of a patient, is a source of embarrassment and distress, and affects anti-leprosy drive adversely in many ways in the field situation. Its management with oral prednisolone alone, the mainstay of treatment for reversal reaction, proved disappointing. Objective: To see whether topical tacrolimus will be helpful in managing those patients. Methodology: We treated five adult patients with recurring reversal reaction in large facial patch with tacrolimus 0.1% ointment, twice daily and lower dose oral prednisolone for twelve months during March, 2012-February, 2013. Result: Complete remission was achieved in all cases. No side effects of whatsoever was seen in any patient. No recurrence of reaction is seen in any patient till to date. Conclusion: Tacrolimus ointment and lower dose prednisolone was found helpful in managing patients with recurring reversal reaction in large facial patch.},
year = {2014}
}
TY - JOUR T1 - Tacrolimus in the Management of Large Facial Patch with Recurring Reversal Reaction: Outcome of a Pilot Clinical Trial Study on 5 Patients AU - Delwar Hossain Y1 - 2014/08/20 PY - 2014 N1 - https://doi.org/10.11648/j.ajcem.20140204.16 DO - 10.11648/j.ajcem.20140204.16 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 86 EP - 89 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20140204.16 AB - Background: Inflamed large facial patch, being compromising the appearance and beauty of a patient, is a source of embarrassment and distress, and affects anti-leprosy drive adversely in many ways in the field situation. Its management with oral prednisolone alone, the mainstay of treatment for reversal reaction, proved disappointing. Objective: To see whether topical tacrolimus will be helpful in managing those patients. Methodology: We treated five adult patients with recurring reversal reaction in large facial patch with tacrolimus 0.1% ointment, twice daily and lower dose oral prednisolone for twelve months during March, 2012-February, 2013. Result: Complete remission was achieved in all cases. No side effects of whatsoever was seen in any patient. No recurrence of reaction is seen in any patient till to date. Conclusion: Tacrolimus ointment and lower dose prednisolone was found helpful in managing patients with recurring reversal reaction in large facial patch. VL - 2 IS - 4 ER -
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