Toxicological Study of the Seed Extracts from <i>Dodonaea madagascariensis</i> Radlk (Sapindaceae), a Malagasy Medicinal Plant

Mihajasoa Stella Razanatseheno; Clara Fredeline Rajemiarimoelisoa; Zoarilala Rinah Razafindrakoto; David Ramanitrahasimbola; Danielle Aurore Doll Rakoto; Hanitra Ranjana Randrianarivo; Victor Louis Jeannoda

doi:doi:10.11648/j.jps.20150306.13

Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant

Mihajasoa Stella Razanatseheno, Clara Fredeline Rajemiarimoelisoa, Zoarilala Rinah Razafindrakoto, David Ramanitrahasimbola, Danielle Aurore Doll Rakoto, Hanitra Ranjana Randrianarivo, Victor Louis Jeannoda

Published in Journal of Plant Sciences (Volume 3, Issue 6)

Received: 26 October 2015 Accepted: 4 November 2015 Published: 19 November 2015

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Abstract

This work was designed to study the seed toxicity of Dodonaea madagascariensis Radlk. (Sapindaceae), an endemic plant to Madagascar with multiple medicinal uses. Using different experimental models of animals, seed methanolic extract of D. madagascariensis (SMED) was found to be toxic to mice (LD50 of 36.12 mg/ kg by intraperitoneal route), chicks (Gallus gallus domesticus), juvenile fishes (Cyprinus carpio) (LC50 of 4.33 µg/mL) and frog tadpoles (Ptychadena mascareniensis) (LC50 of 5.41 µg/mL). Toxicity was ascribed to saponin group only. In mice, SMED developed different symptoms when administered by intraperitoneal, subcutaneous and oral routes. Trailing of the posterior limbs, low body posture, tremors, ataxia, abdominal breathing and at high dose, diarrhea were the most common occurring symptoms. In acute and subchronic administrations, SMED caused damages in the liver, kidneys, lungs, small and large intestines while brain, heart and stomach were not affected. No significant changes on serum concentration of ASAT, ALAT and creatinine were observed after oral subchronic exposure (30 days) to SMED at 12.71 mg/kg. SMED exerted a positive inotropic effect on isolated guinea pig atria at 12.5 µg/mL and had a hemolytic activity. In the light of these preliminary results, the toxicity of D. madagascariensis seeds could be used in the control of harmful cold blooded animals.

Published in	Journal of Plant Sciences (Volume 3, Issue 6)
DOI	10.11648/j.jps.20150306.13
Page(s)	303-309
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Dodonaea madagascariensis, Seed Methanolic Extract, Saponins, Toxicity, Histopathological Lesions, Biochemical Parameters

References

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Mihajasoa Stella Razanatseheno, Clara Fredeline Rajemiarimoelisoa, Zoarilala Rinah Razafindrakoto, David Ramanitrahasimbola, Danielle Aurore Doll Rakoto, et al. (2015). Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant. Journal of Plant Sciences, 3(6), 303-309. https://doi.org/10.11648/j.jps.20150306.13

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ACS Style

Mihajasoa Stella Razanatseheno; Clara Fredeline Rajemiarimoelisoa; Zoarilala Rinah Razafindrakoto; David Ramanitrahasimbola; Danielle Aurore Doll Rakoto, et al. Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant. J. Plant Sci. 2015, 3(6), 303-309. doi: 10.11648/j.jps.20150306.13

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AMA Style

Mihajasoa Stella Razanatseheno, Clara Fredeline Rajemiarimoelisoa, Zoarilala Rinah Razafindrakoto, David Ramanitrahasimbola, Danielle Aurore Doll Rakoto, et al. Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant. J Plant Sci. 2015;3(6):303-309. doi: 10.11648/j.jps.20150306.13

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@article{10.11648/j.jps.20150306.13,
  author = {Mihajasoa Stella Razanatseheno and Clara Fredeline Rajemiarimoelisoa and Zoarilala Rinah Razafindrakoto and David Ramanitrahasimbola and Danielle Aurore Doll Rakoto and Hanitra Ranjana Randrianarivo and Victor Louis Jeannoda},
  title = {Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant},
  journal = {Journal of Plant Sciences},
  volume = {3},
  number = {6},
  pages = {303-309},
  doi = {10.11648/j.jps.20150306.13},
  url = {https://doi.org/10.11648/j.jps.20150306.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jps.20150306.13},
  abstract = {This work was designed to study the seed toxicity of Dodonaea madagascariensis Radlk. (Sapindaceae), an endemic plant to Madagascar with multiple medicinal uses. Using different experimental models of animals, seed methanolic extract of D. madagascariensis (SMED) was found to be toxic to mice (LD50 of 36.12 mg/ kg by intraperitoneal route), chicks (Gallus gallus domesticus), juvenile fishes (Cyprinus carpio) (LC50 of 4.33 µg/mL) and frog tadpoles (Ptychadena mascareniensis) (LC50 of 5.41 µg/mL). Toxicity was ascribed to saponin group only. In mice, SMED developed different symptoms when administered by intraperitoneal, subcutaneous and oral routes. Trailing of the posterior limbs, low body posture, tremors, ataxia, abdominal breathing and at high dose, diarrhea were the most common occurring symptoms. In acute and subchronic administrations, SMED caused damages in the liver, kidneys, lungs, small and large intestines while brain, heart and stomach were not affected. No significant changes on serum concentration of ASAT, ALAT and creatinine were observed after oral subchronic exposure (30 days) to SMED at 12.71 mg/kg. SMED exerted a positive inotropic effect on isolated guinea pig atria at 12.5 µg/mL and had a hemolytic activity. In the light of these preliminary results, the toxicity of D. madagascariensis seeds could be used in the control of harmful cold blooded animals.},
 year = {2015}
}

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TY - JOUR
T1 - Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant
AU - Mihajasoa Stella Razanatseheno
AU - Clara Fredeline Rajemiarimoelisoa
AU - Zoarilala Rinah Razafindrakoto
AU - David Ramanitrahasimbola
AU - Danielle Aurore Doll Rakoto
AU - Hanitra Ranjana Randrianarivo
AU - Victor Louis Jeannoda
Y1 - 2015/11/19
PY - 2015
N1 - https://doi.org/10.11648/j.jps.20150306.13
DO - 10.11648/j.jps.20150306.13
T2 - Journal of Plant Sciences
JF - Journal of Plant Sciences
JO - Journal of Plant Sciences
SP - 303
EP - 309
PB - Science Publishing Group
SN - 2331-0731
UR - https://doi.org/10.11648/j.jps.20150306.13
AB - This work was designed to study the seed toxicity of Dodonaea madagascariensis Radlk. (Sapindaceae), an endemic plant to Madagascar with multiple medicinal uses. Using different experimental models of animals, seed methanolic extract of D. madagascariensis (SMED) was found to be toxic to mice (LD50 of 36.12 mg/ kg by intraperitoneal route), chicks (Gallus gallus domesticus), juvenile fishes (Cyprinus carpio) (LC50 of 4.33 µg/mL) and frog tadpoles (Ptychadena mascareniensis) (LC50 of 5.41 µg/mL). Toxicity was ascribed to saponin group only. In mice, SMED developed different symptoms when administered by intraperitoneal, subcutaneous and oral routes. Trailing of the posterior limbs, low body posture, tremors, ataxia, abdominal breathing and at high dose, diarrhea were the most common occurring symptoms. In acute and subchronic administrations, SMED caused damages in the liver, kidneys, lungs, small and large intestines while brain, heart and stomach were not affected. No significant changes on serum concentration of ASAT, ALAT and creatinine were observed after oral subchronic exposure (30 days) to SMED at 12.71 mg/kg. SMED exerted a positive inotropic effect on isolated guinea pig atria at 12.5 µg/mL and had a hemolytic activity. In the light of these preliminary results, the toxicity of D. madagascariensis seeds could be used in the control of harmful cold blooded animals.
VL - 3
IS - 6
ER -

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Author Information

Mihajasoa Stella Razanatseheno

Laboratory of Applied Biochemistry to Medical Sciences, Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, Antananarivo, Madagascar
Clara Fredeline Rajemiarimoelisoa

Department of Pharmacy, Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar
Zoarilala Rinah Razafindrakoto

Malagasy Institute for Applied Research (IMRA), Antananarivo, Madagascar
David Ramanitrahasimbola

Department of Pharmacy, Faculty of Medicine, University of Antananarivo, Antananarivo, Madagascar
Danielle Aurore Doll Rakoto

Laboratory of Applied Biochemistry to Medical Sciences, Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, Antananarivo, Madagascar
Hanitra Ranjana Randrianarivo

Laboratory of Applied Biochemistry to Medical Sciences, Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, Antananarivo, Madagascar
Victor Louis Jeannoda

Laboratory of Applied Biochemistry to Medical Sciences, Fundamental and Applied Biochemistry Department, Faculty of Sciences, University of Antananarivo, Antananarivo, Madagascar

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APA Style

Mihajasoa Stella Razanatseheno, Clara Fredeline Rajemiarimoelisoa, Zoarilala Rinah Razafindrakoto, David Ramanitrahasimbola, Danielle Aurore Doll Rakoto, et al. (2015). Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant. Journal of Plant Sciences, 3(6), 303-309. https://doi.org/10.11648/j.jps.20150306.13

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ACS Style

Mihajasoa Stella Razanatseheno; Clara Fredeline Rajemiarimoelisoa; Zoarilala Rinah Razafindrakoto; David Ramanitrahasimbola; Danielle Aurore Doll Rakoto, et al. Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant. J. Plant Sci. 2015, 3(6), 303-309. doi: 10.11648/j.jps.20150306.13

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AMA Style

Mihajasoa Stella Razanatseheno, Clara Fredeline Rajemiarimoelisoa, Zoarilala Rinah Razafindrakoto, David Ramanitrahasimbola, Danielle Aurore Doll Rakoto, et al. Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant. J Plant Sci. 2015;3(6):303-309. doi: 10.11648/j.jps.20150306.13

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@article{10.11648/j.jps.20150306.13,
  author = {Mihajasoa Stella Razanatseheno and Clara Fredeline Rajemiarimoelisoa and Zoarilala Rinah Razafindrakoto and David Ramanitrahasimbola and Danielle Aurore Doll Rakoto and Hanitra Ranjana Randrianarivo and Victor Louis Jeannoda},
  title = {Toxicological Study of the Seed Extracts from Dodonaea madagascariensis Radlk (Sapindaceae), a Malagasy Medicinal Plant},
  journal = {Journal of Plant Sciences},
  volume = {3},
  number = {6},
  pages = {303-309},
  doi = {10.11648/j.jps.20150306.13},
  url = {https://doi.org/10.11648/j.jps.20150306.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jps.20150306.13},
  abstract = {This work was designed to study the seed toxicity of Dodonaea madagascariensis Radlk. (Sapindaceae), an endemic plant to Madagascar with multiple medicinal uses. Using different experimental models of animals, seed methanolic extract of D. madagascariensis (SMED) was found to be toxic to mice (LD50 of 36.12 mg/ kg by intraperitoneal route), chicks (Gallus gallus domesticus), juvenile fishes (Cyprinus carpio) (LC50 of 4.33 µg/mL) and frog tadpoles (Ptychadena mascareniensis) (LC50 of 5.41 µg/mL). Toxicity was ascribed to saponin group only. In mice, SMED developed different symptoms when administered by intraperitoneal, subcutaneous and oral routes. Trailing of the posterior limbs, low body posture, tremors, ataxia, abdominal breathing and at high dose, diarrhea were the most common occurring symptoms. In acute and subchronic administrations, SMED caused damages in the liver, kidneys, lungs, small and large intestines while brain, heart and stomach were not affected. No significant changes on serum concentration of ASAT, ALAT and creatinine were observed after oral subchronic exposure (30 days) to SMED at 12.71 mg/kg. SMED exerted a positive inotropic effect on isolated guinea pig atria at 12.5 µg/mL and had a hemolytic activity. In the light of these preliminary results, the toxicity of D. madagascariensis seeds could be used in the control of harmful cold blooded animals.},
 year = {2015}
}

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